VDR Gene variation and insulin resistance related diseases.

ABSTRACT:

Background

Vitamin D status may influence the risk of Insulin resistance related diseases such as Type 2 diabetes (T2DM), metabolic syndrome (MetS), and polycystic ovarian syndrome (PCOS). Several studies have assessed vitamin D receptor (VDR) gene polymorphism in relationship with these diseases; however, results remain inconsistent. Our study was conducted to elucidate whether VDR Gene polymorphisms could predict insulin resistance on a large scale.

Methods

A meta-analysis using MEDLINE and EMBASE, was performed up to December 16th, 2016. Studies reporting association of vitamin D gene polymorphism with incident T2DM, MetS and PCOS outcomes were included and sub-group analysis by pigment of skin and latitude were performed.

Results

A total of 28 articles based on fo

SUBMITTER: Han FF 

PROVIDER: S-EPMC5563043 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature