Genome-wide association study identifies novel type II diabetes risk loci in Jordan subpopulations.

ABSTRACT: The prevalence of Type II Diabetes (T2D) has been increasing and has become a disease of significant public health burden in Jordan. None of the previous genome-wide association studies (GWAS) have specifically investigated the Middle East populations. The Circassian and Chechen communities in Jordan represent unique populations that are genetically distinct from the Arab population and other populations in the Caucasus. Prevalence of T2D is very high in both the Circassian and Chechen communities in Jordan despite low obesity prevalence. We conducted GWAS on T2D in these two populations and further performed meta-analysis of the results. We identified a novel T2D locus at chr20p12.2 at genome-wide significance (rs6134031, P = 1.12 × 10^-8) and we replicated the results in

SUBMITTER: Dajani R 

PROVIDER: S-EPMC5563445 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature