Modeling mammary organogenesis from biological first principles: Cells and their physical constraints.

ABSTRACT: In multicellular organisms, relations among parts and between parts and the whole are contextual and interdependent. These organisms and their cells are ontogenetically linked: an organism starts as a cell that divides producing non-identical cells, which organize in tri-dimensional patterns. These association patterns and cells types change as tissues and organs are formed. This contextuality and circularity makes it difficult to establish detailed cause and effect relationships. Here we propose an approach to overcome these intrinsic difficulties by combining the use of two models; 1) an experimental one that employs 3D culture technology to obtain the structures of the mammary gland, namely, ducts and acini, and 2) a mathematical model based on biological principles. The typical approac

SUBMITTER: Montevil M 

PROVIDER: S-EPMC5563449 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature