α4βδ-GABA_A receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity-based anorexia through localization at excitatory synapses.

ABSTRACT: In hippocampal CA1 of adolescent female rodents, α4βδ-GABA_A receptors (α4βδ-GABA_A Rs) suppress excitability of pyramidal neurons through shunting inhibition at excitatory synapses. This contributes to anxiolysis of stressed animals. Socially isolated adolescent female rats with 8 days of wheel access, the last 4 days of which entail restricted food access, have been shown to exhibit excessive exercise, choosing to run instead of eat (activity-based anorexia [ABA]). Upregulation of α4βδ-GABA_A Rs in the dorsal hippocampal CA1 (DH), seen among some ABA animals, correlates with suppression of excessive exercise. We used electron microscopic immunocytochemistry to show that exercise alone (EX), but not food restriction alone (FR), also augments α4βδ-GABA_A</

SUBMITTER: Aoki C 

PROVIDER: S-EPMC5563482 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature