CLEC5A is a critical receptor in innate immunity against Listeria infection.

ABSTRACT: The C-type lectin member 5A (CLEC5A) is a pattern recognition receptor for members of the Flavivirus family and has critical functions in response to dengue virus and Japanese encephalitis virus. Here we show that CLEC5A is involved in neutrophil extracellular trap formation and the production of reactive oxygen species and proinflammatory cytokines in response to Listeria monocytogenes. Inoculation of Clec5a ^-/- mice with L. monocytogenes causes rapid bacterial spreading, increased bacterial loads in the blood and liver, and severe liver necrosis. In these mice, IL-1β, IL-17A, and TNF expression is inhibited, CCL2 is induced, and large numbers of CD11b⁺Ly6C^hiCCR2^hiCX3CR1^low inflammatory monocytes infiltrate the liver. By day 5 of infe

SUBMITTER: Chen ST 

PROVIDER: S-EPMC5563510 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature