The impact of repeated vaccination on influenza vaccine effectiveness: a systematic review and meta-analysis.

ABSTRACT:

Background

Conflicting results regarding the impact of repeated vaccination on influenza vaccine effectiveness (VE) may cause confusion regarding the benefits of receiving the current season's vaccine.

Methods

We systematically searched MEDLINE, Embase, PubMed, and Cumulative Index to Nursing and Allied Health Literature from database inception to August 17, 2016, for observational studies published in English that reported VE against laboratory-confirmed influenza for four vaccination groups, namely current season only, prior season only, both seasons, and neither season. We pooled differences in VE (∆VE) between vaccination groups by influenza season and type/subtype using a random effects model. The study protocol is registered with PROSPERO (registration number: CRD42016

SUBMITTER: Ramsay LC 

PROVIDER: S-EPMC5563917 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature