A network pharmacology-based strategy deciphers the underlying molecular mechanisms of Qixuehe Capsule in the treatment of menstrual disorders.

ABSTRACT:

Background

QiXueHe Capsule (QXHC) is a Chinese patent drug that is extensively used for the treatment of menstrual disorders. However, its underlying pharmacological mechanisms have not been fully elucidated.

Methods

A list of QXHC putative targets were predicted using MetaDrug. An interaction network using links between QXHC putative targets and the known therapeutic targets of menstrual disorders was constructed. QXHC candidate targets were also identified via calculating the topological feature values of nodes in the network. Additionally, molecular docking simulation was performed to determine the binding efficiency of QXHC compound-putative target pairs.

Results

A total of 1022 putative targets were predicted for 311 chemical components containing in QXHC. Follow

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5563918 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature