Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque.

ABSTRACT: Effector memory T cell (T_EM) responses display potent antiviral properties and have been linked to stringent control of simian immunodeficiency virus (SIV) replication. Since recurrent antigen stimulation drives the differentiation of CD8⁺ T cells toward the T_EM phenotype, in this study we incorporated a persistent herpesviral vector into a heterologous prime/boost/boost vaccine approach to maximize the induction of T_EM responses. This new regimen resulted in CD8⁺ T_EM-biased responses in four rhesus macaques, three of which controlled viral replication to <1,000 viral RNA copies/ml of plasma for more than 6 months after infection with SIVmac239. Over the course of this study, we made a series of interesting observations in o

SUBMITTER: Martins MA 

PROVIDER: S-EPMC5564033 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature