Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein.

ABSTRACT: The avian nucleus laminaris (NL) is a brainstem nucleus necessary for binaural processing, analogous in structure and function to the mammalian medial superior olive. In chickens (Gallus gallus), NL is a well-studied model system for activity-dependent neural plasticity. Its neurons have bipolar extension of dendrites, which receive segregated inputs from two ears and display rapid and compartment-specific reorganization in response to unilateral changes in auditory input. More recently, fragile X mental retardation protein (FMRP), an RNA-binding protein that regulates local protein translation, has been shown to be enriched in NL dendrites, suggesting its potential role in the structural dynamics of these dendrites. To explore the molecular role of FMRP in this nucleus, we performed prote

SUBMITTER: Sakano H 

PROVIDER: S-EPMC5564178 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature