Inference of multiple-wave population admixture by modeling decay of linkage disequilibrium with polynomial functions.

ABSTRACT: To infer the histories of population admixture, one important challenge with methods based on the admixture linkage disequilibrium (ALD) is to remove the effect of source LD (SLD), which is directly inherited from source populations. In previous methods, only the decay curve of weighted LD between pairs of sites whose genetic distance were larger than a certain starting distance was fitted by single or multiple exponential functions, for the inference of recent single- or multiple-wave admixture. However, the effect of SLD has not been well defined and no tool has been developed to estimate the effect of SLD on weighted LD decay. In this study, we defined the SLD in the formularized weighted LD statistic under the two-way admixture model and proposed a polynomial spectrum (p-spectrum) to s

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC5564381 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature