A Functional Toll-Interacting Protein Variant Is Associated with Bacillus Calmette-Guerin-Specific Immune Responses and Tuberculosis.

ABSTRACT:

Rationale

The molecular mechanisms that regulate tuberculosis susceptibility and bacillus Calmette-Guérin (BCG)-induced immunity are mostly unknown. However, induction of the adaptive immune response is a critical step in host control of Mycobacterium tuberculosis. Toll-interacting protein (TOLLIP) is a ubiquitin-binding protein that regulates innate immune responses, including Toll-like receptor signaling, which initiate adaptive immunity. TOLLIP variation is associated with susceptibility to tuberculosis, but the mechanism by which it regulates tuberculosis immunity is poorly understood.

Objectives

To identify functional TOLLIP variants and evaluate the role of TOLLIP variation on innate and adaptive immune responses to mycobacteria and susceptibility to tuberculosis.

M

SUBMITTER: Shah JA 

PROVIDER: S-EPMC5564674 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature