Elevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer.

ABSTRACT: The TATA-binding protein (TBP) plays a central role in eukaryotic gene transcription. Given its key function in transcription initiation, TBP was initially thought to be an invariant protein. However, studies showed that TBP expression is upregulated by oncogenic signaling pathways. Furthermore, depending on the cell type, small increases in cellular TBP amounts can induce changes in cellular growth properties towards a transformed phenotype. Here we sought to identify the specific TBP-regulated gene targets that drive its ability to induce tumorigenesis. Using microarray analysis, our results reveal that increases in cellular TBP concentrations produce selective alterations in gene expression that include an enrichment for genes involved in angiogenesis. Accordingly, we find that TBP leve

SUBMITTER: Johnson SAS 

PROVIDER: S-EPMC5564728 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature