The molecular heterogeneity of sporadic colorectal cancer with different tumor sites in Chinese patients.

ABSTRACT:

Purpose

To assess the biological variability of clinical meaningful molecular markers and their clinical correlations in Chinese patients with colorectal cancer (CRC).

Materials and methods

In this prospective observational study, frequencies and clinico-pathological features of RAS and BRAFV600E mutations, deficiency of DNA mismatch repair (dMMR) were evaluated in patients with colorectal cancer staged I-IV. The molecular heterogeneity between right-sided and left-sided colorectal cancers was studied in our series by classifying patients with different mutations and dMMR status.

Results

Among 400 evaluable patients, mutations in KRAS exon 2, exon 3 or 4, NRAS and BRAFV600E were detected in 36%, 7.5%, 3.5% and 2.5%, respectively. RAS mutations were significantly highe

SUBMITTER: Peng J 

PROVIDER: S-EPMC5564750 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature