DAXX/ATRX and MEN1 genes are strong prognostic markers in pancreatic neuroendocrine tumors.

ABSTRACT:

Background

PanNETs shows heterogeneous biological behaviors. The aim was to investigate prognostic markers based on most frequently mutated genes in PanNETs.

Results

There was a total of 76 patients (M: 39, F: 37) with pathologically proven PanNETs. ATRX/DAXX and MEN1 protein expression was detected in 16 (21%) and 31 (41%) patients, respectively. The mean OS of the total study patients was 16 years, and DFS was 17 years among the 68 patients with curative resections. PanNETs presented with distant metastasis or loss of ATRX/DAXX protein expression was the independent prognostic factors associated with poor OS. In curative resected PanNETs, there was no significant difference in the mean DFS according to ATRX/DAXX or MEN1 protein. However, there was statistically significant

SUBMITTER: Park JK 

PROVIDER: S-EPMC5564808 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature