Estimation of bladder contractility from intravesical pressure-volume measurements.

ABSTRACT:

Aims

To describe parameters from urodynamic pressure recordings that describe urinary bladder contractility through the use of principles of muscle mechanics.

Methods

Subtracted detrusor pressure and voided flow were recorded from patients undergoing filling cystometry. The isovolumetric increase of detrusor pressure, P, of a voluntary bladder contraction before voiding was used to generate a plot of (dP/dt)/P versus P. Extrapolation of the plot to the y-axis and the x-axis generated a contractility parameter, v_CE (the maximum rate of pressure development) and the maximum isovolumetric pressure, P₀ , respectively. Similar curves were obtained in ex vivo pig bladders with different concentrations of the inotropic agent carbachol and shown in a supplement

SUBMITTER: Fry CH 

PROVIDER: S-EPMC5565196 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature