Evidence for frequency-dependent cortical plasticity in the human brain.

ABSTRACT: Frequency-dependent plasticity (FDP) describes adaptation at the synapse in response to stimulation at different frequencies. Its consequence on the structure and function of cortical networks is unknown. We tested whether cortical "resonance," favorable stimulation frequencies at which the sensory cortices respond maximally, influenced the impact of FDP on perception, functional topography, and connectivity of the primary somatosensory cortex using psychophysics and functional imaging (fMRI). We costimulated two digits on the hand synchronously at, above, or below the resonance frequency of the somatosensory cortex, and tested subjects' accuracy and speed on tactile localization before and after costimulation. More errors and slower response times followed costimulation at above- or below

SUBMITTER: Lea-Carnall CA 

PROVIDER: S-EPMC5565407 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature