Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies.

ABSTRACT: The recent outbreak of Zika virus (ZIKV) has been associated with fetal abnormalities and neurological complications, prompting global concern. Here we present a mathematical analysis of the within-host dynamics of plasma ZIKV burden in a nonhuman primate model, allowing for characterization of the growth and clearance of ZIKV within individual macaques. We estimate that the eclipse phase for ZIKV, the time between cell infection and viral production, is most likely short (∼4 h), the median within-host basic reproductive number R₀ is 10.7, the rate of viral production is rapid (>25,000 virions d^-1), and the lifetime of an infected cell while producing virus is ∼5 h. We also estimate that the minimum number of virions produced by an infected cell over its

SUBMITTER: Best K 

PROVIDER: S-EPMC5565429 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature