HDL cholesterol: reappraisal of its clinical relevance.

ABSTRACT:

Background

While several lines of evidence prove that elevated concentrations of low-density lipoproteins (LDL) causally contribute to the development of atherosclerosis and its clinical consequences, high-density lipoproteins are still widely believed to exert atheroprotective effects. Hence, HDL cholesterol (HDL-C) is in general still considered as "good cholesterol". Recent research, however, suggests that this might not always be the case and that a fundamental reassessment of the clinical significance of HDL-C is warranted.

Method

This review article is based on a selective literature review.

Results

In individuals without a history of cardiovascular events, low concentrations of HDL-C are inversely associated with the risk of future cardiovascular events. This r

SUBMITTER: Marz W 

PROVIDER: S-EPMC5565659 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature