Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa.

ABSTRACT:

Background

Anorexia Nervosa (AN) is a serious mental illness characterized by emaciation, an intense fear of gaining weight despite being underweight, and distorted body image. Few treatments reverse the core symptoms in AN such as profound aversion to food and food avoidance. Consequently, AN has a chronic and relapsing course and the highest mortality rate of any psychiatric illness. A more complete understanding of the disease pathogenesis is needed in order to develop better treatments and improve AN outcome. The pathogenesis and psychopathophysiology of AN can be better elucidated by combining longitudinal phenotyping with multiple "omics" techniques, including genomics, proteomics, lipidomics, and metabolomics.

Design

This paper summarizes the key findings of a series

SUBMITTER: Shih PB 

PROVIDER: S-EPMC5565718 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature