Do patient characteristics moderate the effect of extended-release naltrexone (XR-NTX) for opioid use disorder?

ABSTRACT:

Background

Extended release naltrexone (XR-NTX) injected intramuscularly monthly has been shown to reduce relapse in persons with opioid use disorder. Baseline factors, including patients' demographics, comorbidities and lifestyle, may help identify patients who will benefit most or least from XR-NTX treatment.

Methods

Potential moderators of XR-NTX's effect were examined in the largest North American randomized open-label effectiveness trial of XR-NTX. Relapse status (Yes/No) at 6-month follow-up was regressed on treatment group (XR-NTX, N=153; or Treatment-as-Usual [TAU], N=155), baseline covariates, and their two-way interaction to identify moderator effects. Baseline covariates included age, gender, summary scores for depression, suicidal thoughts, drug abuse risk, subst

SUBMITTER: Friedmann PD 

PROVIDER: S-EPMC5565721 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature