Pd-Catalyzed Hydroamination of Alkoxyallenes with Azole Heterocycles: Examples and Mechanistic Proposal.

ABSTRACT: Palladium-catalyzed regio- and enantioselective addition of azole heterocycles to alkoxyallenes was developed (up to 92% yields and up to 94% ee). DFT calculations suggest a new Pd(0)-driven mechanistic pathway proceeding through protonation of the Pd-coordinated allene (4-PdL₂), which develops a strongly nucleophilic character at the central C atom.

SUBMITTER: Bernar I 

PROVIDER: S-EPMC5565904 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature