The endothelin B receptor plays a crucial role in the adhesion of neutrophils to the endothelium in sickle cell disease.

ABSTRACT: Although the primary origin of sickle cell disease is a hemoglobin disorder, many types of cells contribute considerably to the pathophysiology of the disease. The adhesion of neutrophils to activated endothelium is critical in the pathophysiology of sickle cell disease and targeting neutrophils and their interactions with endothelium represents an important opportunity for the development of new therapeutics. We focused on endothelin-1, a mediator involved in neutrophil activation and recruitment in tissues, and investigated the involvement of the endothelin receptors in the interaction of neutrophils with endothelial cells. We used fluorescence intravital microscopy analyses of the microcirculation in sickle mice and quantitative microfluidic fluorescence microscopy of human blood. Both

SUBMITTER: Koehl B 

PROVIDER: S-EPMC5566019 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature