APMAP interacts with lysyl oxidase-like proteins, and disruption of <i>Apmap</i> leads to beneficial visceral adipose tissue expansion.

ABSTRACT: Adipocyte plasma membrane-associated protein (APMAP) has been described as an adipogenic factor in 3T3-L1 cells with unknown biochemical function; we therefore aimed to investigate the physiologic function of APMAP in vivo We generated Apmap-knockout mice and challenged them with an obesogenic diet to investigate their metabolic phenotype. We identified a novel truncated adipocyte-specific isoform of APMAP in mice that is produced by alternative transcription. Mice lacking the full-length APMAP protein, the only isoform that is expressed in humans, have an improved metabolic phenotype upon diet-induced obesity, indicated by enhanced insulin sensitivity, preserved glucose tolerance, increased respiratory exchange ratio, decreased inflammatory marker gene expression, and reduce

SUBMITTER: Pessentheiner AR 

PROVIDER: S-EPMC5566180 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature