Immune system deregulation in hypertensive patients chronically RAS suppressed developing albuminuria.

ABSTRACT: Albuminuria development in hypertensive patients is an indicator of higher cardiovascular (CV) risk and renal damage. Chronic renin-angiotensin system (RAS) suppression facilitates blood pressure control but it does not prevent from albuminuria development. We pursued the identification of protein indicators in urine behind albuminuria development in hypertensive patients under RAS suppression. Urine was collected from 100 patients classified in three groups according to albuminuria development: (a) patients with persistent normoalbuminuria; (b) patients developing de novo albuminuria; (c) patients with maintained albuminuria. Quantitative analysis was performed in a first discovery cohort by isobaric labeling methodology. Alterations of proteins of interest were confirmed by target mass s

SUBMITTER: Martin-Lorenzo M 

PROVIDER: S-EPMC5566220 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature