Synthesis and Optimization of MoS₂@Fe₃O₄-ICG/Pt(IV) Nanoflowers for MR/IR/PA Bioimaging and Combined PTT/PDT/Chemotherapy Triggered by 808 nm Laser.

ABSTRACT: Elaborately designed biocompatible nanoplatforms simultaneously achieving multimodal bioimaging and therapeutic functions are highly desirable for modern biomedical applications. Herein, uniform MoS₂ nanoflowers with a broad size range of 80-180 nm have been synthesized through a facile, controllable, and scalable hydrothermal method. The strong absorbance of MoS₂ nanoflowers at 808 nm imparts them with high efficiency and stability of photothermal conversion. Then a novel multifunctional composite of MoS₂@Fe₃O₄-ICG/Pt(IV) (labeled as Mo@Fe-ICG/Pt) is designed by covalently grafting Fe₃O₄ nanoparticles with polyethylenimine (PEI) functionalized MoS₂, and then loading indocyanine green molecules (ICG, ph

SUBMITTER: Liu B 

PROVIDER: S-EPMC5566229 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature