Bisphenol A Impairs Synaptic Plasticity by Both Pre- and Postsynaptic Mechanisms.

ABSTRACT: Bisphenol A (BPA), an environmental xenoestrogen, has been reported to induce learning and memory impairments in rodent animals. However, effects of BPA exposure on synaptic plasticity and the underlying physiological mechanisms remain elusive. Our behavioral and electrophysiological analyses show that BPA obviously perturbs hippocampal spatial memory of juvenile Sprague-Dawley rats after four weeks exposure, with significantly impaired long-term potentiation (LTP) in the hippocampus. These effects involve decreased spine density of pyramidal neurons, especially the apical dendritic spine. Further presynaptic findings show an overt inhibition of pulse-paired facilitation during electrophysiological recording, which suggest the decrease of presynaptic transmitter release and is consistent w

SUBMITTER: Hu F 

PROVIDER: S-EPMC5566242 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature