Ontology highlight
ABSTRACT:
SUBMITTER: Lu X
PROVIDER: S-EPMC5566419 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Lu Xuan X Huang Changjing C Zhang Yi Y Lin Yong Y Wang Xueyu X Li Qian Q Liu Shi S Tang Jingfeng J Zhou Li L
Scientific reports 20170821 1
HSV-2 is one of the most common sexually transmitted pathogens worldwide and HSV-2 infection triggers cytokine and chemokine production. However, little is known about which HSV-2 genes engage in the regulation of NF-κB signaling and what mechanisms are involved. In a screen of the unique short (Us) regions of HSV-2, we observed that HSV-2 Us2 activates NF-κB signaling. We additionally indicated that deficiencies of Us2 decrease HSV-2 WT mediated NF-κB activation and cytokine and chemokine produ ...[more]