Optical µ-Printing of Cellular-Scale Microscaffold Arrays for 3D Cell Culture.

ABSTRACT: Guiding cell culture via engineering extracellular microenvironment has attracted tremendous attention due to its appealing potentials in the repair, maintenance, and development of tissues or even whole organs. However, conventional biofabrication technologies are usually less productive in fabricating microscale three-dimensional (3D) constructs because of the strident requirements in processing precision and complexity. Here we present an optical µ-printing technology to rapidly fabricate 3D microscaffold arrays for 3D cell culture and cell-scaffold interaction studies on a single chip. Arrays of 3D cubic microscaffolds with cubical sizes matching the single-cell size were fabricated to facilitate cell spreading on suspended microbeams so as to expose both apical and basal cell membrane

SUBMITTER: Ouyang X 

PROVIDER: S-EPMC5566436 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature