Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naive Individuals.

ABSTRACT: We investigated (1) the relationship between low-density lipoprotein cholesterol (LDL-C) and vascular function in patients receiving and those not receiving statin therapy and (2) optimal level of LDL-C for maintenance of vascular function. Flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) were inversely correlated with LDL-C in the 957 statin naïve subjects but not in the 392 subjects receiving statin therapy. In statin naïve subjects, non-high LDL-C (≤100 mg/dL) was independently associated with a decrease in adjusted odds ratio of the low tertile of FMD (OR: 0.62, 95% CI: 0.45-0.85; P = 0.003) and NID (OR: 0.69, 95% CI: 0.50-0.96; P = 0.03). Adjusted odds ratio of the low tertile of FMD was significantly lower in the low LDL-C group (≤70 mg/dL) (OR: 0.47, 95

SUBMITTER: Matsui S 

PROVIDER: S-EPMC5566450 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature