Physiology-Based Modeling May Predict Surgical Treatment Outcome for Obstructive Sleep Apnea.

ABSTRACT:

Study objectives

To test whether the integration of both anatomical and nonanatomical parameters (ventilatory control, arousal threshold, muscle responsiveness) in a physiology-based model will improve the ability to predict outcomes after upper airway surgery for obstructive sleep apnea (OSA).

Methods

In 31 patients who underwent upper airway surgery for OSA, loop gain and arousal threshold were calculated from preoperative polysomnography (PSG). Three models were compared: (1) a multiple regression based on an extensive list of PSG parameters alone; (2) a multivariate regression using PSG parameters plus PSG-derived estimates of loop gain, arousal threshold, and other trait surrogates; (3) a physiological model incorporating selected variables as surrogates of anatomical a

SUBMITTER: Li Y 

PROVIDER: S-EPMC5566458 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature