Transcriptional control of motility enables directional movement of Escherichia coli in a signal gradient.

ABSTRACT: Manipulation of cellular motility using a target signal can facilitate the development of biosensors or microbe-powered biorobots. Here, we engineered signal-dependent motility in Escherichia coli via the transcriptional control of a key motility gene. Without manipulating chemotaxis, signal-dependent switching of motility, either on or off, led to population-level directional movement of cells up or down a signal gradient. We developed a mathematical model that captures the behaviour of the cells, enables identification of key parameters controlling system behaviour, and facilitates predictive-design of motility-based pattern formation. We demonstrated that motility of the receiver strains could be controlled by a sender strain generating a signal gradient. The modular quorum sensing-depe

SUBMITTER: Ravichandar JD 

PROVIDER: S-EPMC5566481 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature