Ontology highlight
ABSTRACT:
SUBMITTER: Tang X
PROVIDER: S-EPMC5566498 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Tang Xiaolong X Shi Lei L Xie Ni N Liu Zuojun Z Qian Minxian M Meng Fanbiao F Xu Qingyang Q Zhou Mingyan M Cao Xinyue X Zhu Wei-Guo WG Liu Baohua B
Nature communications 20170822 1
Distant metastasis is the main cause of breast cancer-related death; however, effective therapeutic strategies targeting metastasis are still scarce. This is largely attributable to the spatiotemporal intratumor heterogeneity during metastasis. Here we show that protein deacetylase SIRT7 is significantly downregulated in breast cancer lung metastases in human and mice, and predicts metastasis-free survival. SIRT7 deficiency promotes breast cancer cell metastasis, while temporal expression of Sir ...[more]