The gluconate shunt is an alternative route for directing glucose into the pentose phosphate pathway in fission yeast.

ABSTRACT: Glycolysis and the pentose phosphate pathway both play a central role in the degradation of glucose in all domains of life. Another metabolic route that can facilitate glucose breakdown is the gluconate shunt. In this shunt glucose dehydrogenase and gluconate kinase catalyze the two-step conversion of glucose into the pentose phosphate pathway intermediate 6-phosphogluconate. Despite the presence of these enzymes in many organisms, their only established role is in the production of 6-phosphogluconate for the Entner-Doudoroff pathway. In this report we performed metabolic profiling on a strain of Schizosaccharomyces pombe lacking the zinc-responsive transcriptional repressor Loz1 with the goal of identifying metabolic pathways that were altered by cellular zinc status. This profilin

SUBMITTER: Corkins ME 

PROVIDER: S-EPMC5566534 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature