Distinctive Surface Glycosylation Patterns Associated With Mouse and Human CD4⁺ Regulatory T Cells and Their Suppressive Function.

ABSTRACT: Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface glycosylation is ubiquitous on mammalian cells and regulates diverse biological processes. While it is currently well accepted that surface glycan expression influences multiple aspects of T-cell function, little is known about the relevance of glycosylation to Treg biology. This study aimed to profile the surface glycosylation characteristics of Treg in various lymphoid compartments of mouse and in human peripheral blood with comparison to non-regulatory, conventional CD4⁺ T-cells (Tconv). It also sought to determine the relationship between the surface glycosylation characteristics and suppressive potency of Treg. Lectin-based flow cytometric profiling demonstrated that Treg surfa

SUBMITTER: Cabral J 

PROVIDER: S-EPMC5566562 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature