Comprehensive proteome analysis of human skeletal muscle in cachexia and sarcopenia: a pilot study.

ABSTRACT:

Background

Cancer cachexia (cancer-induced muscle wasting) is found in a subgroup of cancer patients leaving the patients with a poor prognosis for survival due to a lower tolerance of the chemotherapeutic drug. The cause of the muscle wasting in these patients is not fully understood, and no predictive biomarker exists to identify these patients early on. Skeletal muscle loss is an inevitable consequence of advancing age. As cancer frequently occurs in old age, identifying and differentiating the molecular mechanisms mediating muscle wasting in cancer cachexia vs. age-related sarcopenia are a challenge. However, the ability to distinguish between them is critical for early intervention, and simple measures of body weight may not be sufficiently sensitive to detect cachexia early.<

SUBMITTER: Ebhardt HA 

PROVIDER: S-EPMC5566647 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature