Variants in TTC25 affect autistic trait in patients with autism spectrum disorder and general population.

ABSTRACT: Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder with a complex genetic architecture. To identify genetic variants underlying ASD, we performed single-variant and gene-based genome-wide association studies using a dense genotyping array containing over 2.3 million single-nucleotide variants in a discovery sample of 160 families with at least one child affected with non-syndromic ASD using a binary (ASD yes/no) phenotype and a quantitative autistic trait. Replication of the top findings was performed in Psychiatric Genomics Consortium and Erasmus Rucphen Family (ERF) cohort study. Significant association of quantitative autistic trait was observed with the TTC25 gene at 17q21.2 (effect size=10.2, P-value=3.4 × 10^-7) in the gene-based analysis. The

SUBMITTER: Vojinovic D 

PROVIDER: S-EPMC5567150 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature