Dysivillosins A-D, Unusual Anti-allergic Meroterpenoids from the Marine Sponge Dysidea villosa.

ABSTRACT: Four unusual meroterpenoids, dysivillosins A-D (1-4), were isolated from an organic extract of the marine sponge Dysidea villosa collected from the South China Sea. Their planar structures were determined by 1D and 2D NMR and HRESIMS techniques, while the relative and absolute configurations were elucidated by NOESY experiments and comparison between the calculated and experimental ECD spectra. To the best of our knowledge, dysivillosins A-D are the first examples of terpene-polyketide-pyridine hybrid metabolites from the nature. Anti-allergic activity evaluation showed that compounds 1-4 potently inhibited the release of β-hexosaminidase, a marker of degranulation, in a dose-dependent manner with IC₅₀ values of 8.2-19.9 μM. Additionally, the four meroterpenoids could downregula

SUBMITTER: Jiao WH 

PROVIDER: S-EPMC5567184 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature