Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis.

ABSTRACT: IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored. We investigated a combinatorial approach for the analysis of IgAN-relevant -omics data, aiming at identification of novel molecular signatures of the disease. Nine published urinary proteomics datasets were collected and the reported differentially expressed proteins in IgAN vs. healthy controls were integrated into known biological pathways. Proteins participating in these pathways were subjected to multi-step assessment, including investigation of IgAN transcriptomics datasets (Nephroseq database), their reported protein-protein interactions (STRING database), kidney

SUBMITTER: Krochmal M 

PROVIDER: S-EPMC5567309 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature