Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia.

ABSTRACT:

Objective

To determine whether logopenic features of phonologic loop dysfunction reflect Alzheimer disease (AD) neuropathology in primary progressive aphasia (PPA).

Methods

We performed a retrospective case-control study of 34 patients with PPA with available autopsy tissue. We compared baseline and longitudinal clinical features in patients with primary AD neuropathology to those with primary non-AD pathologies. We analyzed regional neuroanatomic disease burden in pathology-defined groups using postmortem neuropathologic data.

Results

A total of 19/34 patients had primary AD pathology and 15/34 had non-AD pathology (13 frontotemporal lobar degeneration, 2 Lewy body disease). A total of 16/19 (84%) patients with AD had a logopenic spectrum phenotype; 5 met published c

SUBMITTER: Giannini LAA 

PROVIDER: S-EPMC5567322 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature