Screening of genetic variants in ADCYAP1R1, MME and 14q21 in a Swedish cluster headache cohort.

ABSTRACT:

Background

We have genotyped a Swedish cluster headache case-control population for three genetic variants representing the most significant markers identified in a recently published genome wide association study on cluster headache. The genetic variants were two common polymorphisms; rs12668955 in ADCYAP1R1 (adenylate cyclase activating polypeptide 1 receptor type 1), rs1006417, an intergenic variant on chromosome 14q21 and one rare mutation, rs147564881, in MME (membrane metalloendopeptidase).

Results

We screened 542 cluster headache patients and 581 controls using TaqMan real-time PCR on a 7500 fast cycler, and pyrosequencing on a PSQ 96 System. Statistical analysis for genotype and allele association showed that neither of the two common variants, rs12668955 and rs10064

SUBMITTER: Ran C 

PROVIDER: S-EPMC5567453 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature