Non-Steroidal Anti-Inflammatory Drug Use and the Risk of Acute Myocardial Infarction in the General German Population: A Nested Case-Control Study.

ABSTRACT:

Introduction

Use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with an increased relative risk of acute myocardial infarction (AMI), but the label warnings refer particularly to patients with cardiovascular risk factors. The magnitude of relative AMI risk for patients with and without cardiovascular risk factors varies between studies depending on the drugs and doses studied.

Objectives

The aim of our study was to estimate population-based relative AMI risks for individual and widely used NSAIDs, for a cumulative amount of NSAID use, and for patients with and without a prior history of cardiovascular risk factors.

Methods

Based on data from the German Pharmacoepidemiological Research Database (GePaRD) of about 17 million insurance members from

SUBMITTER: Thone K 

PROVIDER: S-EPMC5567458 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature