Tum1 is involved in the metabolism of sterol esters in Saccharomyces cerevisiae.

ABSTRACT:

Background

The only hitherto known biological role of yeast Saccharomyces cerevisiae Tum1 protein is in the tRNA thiolation pathway. The mammalian homologue of the yeast TUM1 gene, the thiosulfate sulfurtransferase (a.k.a. rhodanese) Tst, has been proposed as an obesity-resistance and antidiabetic gene. To assess the role of Tum1 in cell metabolism and the putative functional connection between lipid metabolism and tRNA modification, we analysed evolutionary conservation of the rhodanese protein superfamily, investigated the role of Tum1 in lipid metabolism, and examined the phenotype of yeast strains expressing the mouse homologue of Tum1, TST.

Results

We analysed evolutionary relationships in the rhodanese superfamily and established that its members are widespread in bact

SUBMITTER: Ursic K 

PROVIDER: S-EPMC5567475 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature