α-Actinin Induces a Kink in the Transmembrane Domain of β₃-Integrin and Impairs Activation via Talin.

ABSTRACT: Integrin-mediated signaling is crucial for cell-substrate adhesion and can be triggered from both intra- and extracellular interactions. Although talin binding is sufficient for inside-out activation of integrin, other cytoplasmic proteins such as α-actinin and filamin can directly interfere with talin-mediated integrin activation. Specifically, α-actinin plays distinct roles in regulating α_IIbβ₃ versus α₅β₁ integrin. It has been shown that α-actinin competes with talin for binding to the cytoplasmic tail of β₃-integrin, whereas it cooperates with talin for activating integrin α₅β₁. In this study, molecular dynamics simulations were employed to compare and contrast molecular mechanisms of α_IIbβ₃

SUBMITTER: Shams H 

PROVIDER: S-EPMC5567591 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature