Emergence and clonal transmission of multi-drug-resistant tuberculosis among patients in Chad.

ABSTRACT:

Background

Emergence of Multidrug-resistant (MDR) strains constitutes a significant public health problem worldwide. Prevalence of MDR tuberculosis from Chad is unavailable to date.

Methods

We collected samples from consecutive TB patients nationwide in the seven major cities of Chad between 2007 and 2012 to characterize drug resistance and the population structure of circulating Mycobacterium tuberculosis complex (MTBC) strains. We tested drug sensitivity using Line Probe Assays and phenotypic drug susceptibility testing (DST) were used for second line drugs. We genotyped the isolates using spoligotype analysis and MIRU-VNTR.

Results

A total of 311 cultures were isolated from 593 patients. The MDR prevalence was 0.9% among new patients and 3.5% among retreatment pati

SUBMITTER: Ba Diallo A 

PROVIDER: S-EPMC5567628 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature