Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy.

ABSTRACT: Aggregation of misfolded proteins or peptides is a common feature of neurodegenerative diseases including Alzheimer's, Parkinson's, Huntington's, prion and other diseases. Recent years have witnessed a growing number of reports of overlap in neuropathological features that were once thought to be unique to only one neurodegenerative disorder. However, the origin for the overlap remains unclear. One possibility is that diseases with mixed brain pathologies might arise from cross-seeding of one amyloidogenic protein by aggregated states of unrelated proteins. In the current study we examined whether prion replication can be induced by cross-seeding by α-synuclein or Aβ peptide. We found that α-synuclein aggregates formed in cultured cells or in vitro display cross-seeding activity and trigge

SUBMITTER: Katorcha E 

PROVIDER: S-EPMC5567908 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature