Hippocampal Response to a 24-Month Physical Activity Intervention in Sedentary Older Adults.

ABSTRACT:

Background

Greater hippocampal volume is observed in healthy older adults after short-term structured exercise. Whether long-term exposure to real-world physical activity (PA) programs has similar effects for sedentary older adults with impaired mobility and comorbid conditions is not known.

Hypothesis

A long-term moderate intensity regimen of PA is related to larger volume of the hippocampus in older adults at risk for mobility disability. We further explore whether these associations are modified by factors known to be related to dementia.

Methods

Twenty-six sedentary adults at risk for mobility disability participated in a 24-month randomized intervention program of physical activity (PA, N = 10, age: 74.9 years, 7 women) or health education (HE, N = 16, age: 76.8

SUBMITTER: Rosano C 

PROVIDER: S-EPMC5568026 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature