Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population.

ABSTRACT:

Background

There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population.

Methods

A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms.

Results

In the univariate modeling, the CC geno

SUBMITTER: Bienertova-Vasku J 

PROVIDER: S-EPMC5568207 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature