IL-18 associated with lung lymphoid aggregates drives IFNγ production in severe COPD.

ABSTRACT:

Background

Increased interferon gamma (IFNγ) release occurs in Chronic Obstructive Pulmonary Disease (COPD) lungs. IFNγ supports optimal viral clearance, but if dysregulated could increase lung tissue destruction.

Methods

The present study investigates which mediators most closely correlate with IFNγ in sputum in stable and exacerbating disease, and seeks to shed light on the spatial requirements for innate production of IFNγ, as reported in mouse lymph nodes, to observe whether such microenvironmental cellular organisation is relevant to IFNγ production in COPD lung.

Results

We show tertiary follicle formation in severe disease alters the dominant mechanistic drivers of IFNγ production, because cells producing interleukin-18, a key regulator of IFNγ, are highly assoc

SUBMITTER: Briend E 

PROVIDER: S-EPMC5568255 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature