Identification of a homogenous structural basis for oligomerization by retroviral Rev-like proteins.

ABSTRACT:

Background

Rev-like proteins are post-transcriptional regulatory proteins found in several retrovirus genera, including lentiviruses, betaretroviruses, and deltaretroviruses. These essential proteins mediate the nuclear export of incompletely spliced viral RNA, and act by tethering viral pre-mRNA to the host CRM1 nuclear export machinery. Although all Rev-like proteins are functionally homologous, they share less than 30% sequence identity. In the present study, we computationally assessed the extent of structural homology among retroviral Rev-like proteins within a phylogenetic framework.

Results

We undertook a comprehensive analysis of overall protein domain architecture and predicted secondary structural features for representative members of the Rev-like family of protei

SUBMITTER: Umunnakwe CN 

PROVIDER: S-EPMC5568270 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature