Genetic and codon usage bias analyses of polymerase genes of equine influenza virus and its relation to evolution.

ABSTRACT:

Background

Equine influenza is a major health problem of equines worldwide. The polymerase genes of influenza virus have key roles in virus replication, transcription, transmission between hosts and pathogenesis. Hence, the comprehensive genetic and codon usage bias of polymerase genes of equine influenza virus (EIV) were analyzed to elucidate the genetic and evolutionary relationships in a novel perspective.

Results

The group - specific consensus amino acid substitutions were identified in all polymerase genes of EIVs that led to divergence of EIVs into various clades. The consistent amino acid changes were also detected in the Florida clade 2 EIVs circulating in Europe and Asia since 2007. To study the codon usage patterns, a total of 281,324 codons of polymerase genes of

SUBMITTER: Bera BC 

PROVIDER: S-EPMC5568313 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature